Job Application

Position: Site Relations

Location: Remote

Reports to: VP, Clinical Development


ContraFect Corporation, a late-stage clinical biotechnology company focused on the discovery and development of biotherapeutics for life-threatening, drug-resistant infectious diseases is located in Westchester County, near New York City. ContraFect is dedicated to innovative drug development, leveraging novel technologies to create new therapies that address the high unmet medical needs of patients suffering from serious, antibiotic-resistant  infections for which there are limited available treatment options. ContraFect is using their technical expertise to develop biotherapeutics for serious bacterial infections, including those caused by MDR and XDR strains that have high unmet medical needs, particularly products used in hospital-based markets.

An opportunity is available to grow with us in an environment that is both challenging and energetic. ContraFect is seeking self-motivated and collaborative individuals to join our team and to contribute their talent and expertise to the team. We are looking for positive individuals who will add the strength of their personality to our committed and dedicated employee base and contribute to the development of novel therapeutic agents which have the potential to change the therapeutic landscape for treating serious infections.

It is an exciting time in ContraFect’s history as we advance our direct lytic agent (DLA) platform of lysins and amurin peptides.  Exebacase (CF-301), our lead lysin, is the first and only direct lytic agent to report promising results in Phase 2 and to advance to Phase 3 clinical development. Earlier this year, the FDA granted Breakthrough Therapy designation to exebacase as a treatment for  MRSA bloodstream infections (bacteremia), including right-sided endocarditis, when used in addition to standard-of-care anti-staphylococcal antibiotics.  The exebacase Phase 3 study, known as the DISRUPT Study (“Direct Lysis of Staphylococcus aureus Resistant Pathogen Trial”), is  ongoing in the United States and will serve as the single pivotal trial to support the BLA.   ContraFect also has an active discovery pipeline of DLAs discovered at ContraFect which are progressing towards the clinic with support from major funding agencies.  Our lead IND candidate, CF-370, is a lysin targeting MDR Pseudomonas aeruginosa, identified as a serious threat in the CDC’s Antibiotic Threats in the US, 2019 report., while our amurin program targets Gram-negative ESKAPE pathogens.

ContraFect has been highly successful in raising significant capital to fund our continued commitment to innovative R&D.  This includes non-dilutive funding up to $86.8 million from BARDA for exebacase clinical development against S. aureus infections, $18.9 million from CARB-X for antibacterial research, $7.2 million from USAMRMC to advance CF-296 for osetomeyelitis, an additional $6.94 million from CARB-X to support the development of the amurin platform against Gram-negative ESKAPE pathogens, and funding from the Cystic Fibrosis Foundation. ContraFect has also conducted numerous capital raises, including public and private offerings. The gross proceeds from the most recent public offering were approximately $52.5 million, and an additional $3 million from a concurrent private placement transaction with Pfizer, the pharmaceutical company’s second investment in ContraFect.

Position Summary:

The Site Relations Manager (SRM) will be responsible for maintaining a positive relationship between ContraFect and the study sites, training of site staff to improve recruitment and study quality oversight (source data verification) of assigned studies. The SRM will execute these responsibilities in accordance with ContraFect’s standard operating procedures (SOP)/processes. This position will also take on additional project management responsibilities as delegated by the Clinical Operations Lead.  This role requires an individual with demonstrable clinical operations and/or study coordinator experience and proven expertise in customer service.  Travel within the contintential US visiting study sites will be required when travel is deemed safe after the COVID-19 pandemic.  The ideal candidate will have a track record of accomplishments in the life sciences/pharmaceutical/biotechnology industry.

Key Responsibilities:

Support site recruitment efforts and enhance enrollment of the clinical study

  • Build relationships with investigators, study coordinators, and other key members at clinical sites to reduce barriers to enrollment and enhance screening activities at the clinical sites.
  • Review pre-screening, screening, and enrollment activities of sites to determine issues at sites, reporting to the CRO/ContraFect CRAs and clinical operations teams, and setting up engagement activities (e.g., face-to-face meetings, telephone calls) with the sites to discuss these issues.
  • Visiting sites in person (at least 6 to 8 sites per month) and telephone communications (at least 10 sites per week) to engage sites about the study and work through any issues the sites are experiencing
  • Develop study related materials to help with recruitment (e.g., posters, flyers, pocket cards, badges, buttons, dear colleague letter)
  • Training site personnel as needed

Create a positive and impactful site experience

  • Identifying and prioritising unique site needs with ongoing, regular communication, teamwork and coordination
  • Sharing relevant insights back to the organisation and following compliance guidelines


  • Bachelor of Science degree or equivalent combination of education and work experience
  • 2-5 years of mid- or late-stage clinical trial experience, clinical monitoring and/or study coordinator experience
  • Thorough knowledge of clinical trial processes including a strong grasp of US guidelines and regulations
  • Thoughtful collaborator and excellent relationship-building skills with the ability to work effectively with internal and external stakeholders
  • Strong entrepreneurial orientation along with teamwork skills with the highest level of integrity
  • Strategic, with an ability to incorporate new data into clinical development planning
  • Excellent technical skills, proficient in MS Word, Excel, Powerpoint, etc.
  • Ability to work efficiently from home based office with occasional travel to main office
  • Travel up to approximately 50% within contintental Unites States 

ContraFect’s Values:

Respect.  People matter.
Patient- Focus.  Act with urgency and passion to save lives.
Leadership.  Set high standards, and empower others to do the same.
Innovation.  Challenge the status quo to deliver solutions.
Collaboration.  Work together to achieve our vision.
Quality.  Strive for excellence in all that we do.
Integrity.  Courage to be honest, ethical, and transparent.

ContraFect does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.


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