Publications / Posters :: ContraFect Corporation (CFRX)

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Publications

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

The Journal of Clinical Investigation, Volume 130, Issue 7, July 1, 2020

Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

Antimicrobial Agents & Chemotherapy, (2019) 63 (10) e01078-19

In vitro activity of Exebacase (CF-301) against clinical Staphylococcus aureus surveillance isolates from the United States, Europe, and Latin America, 2015–2017

Diagnostic Microbiology and Infectious Disease, Volume 95, Issue 4, December 2019, 114879

Postantibiotic and Sub-MIC Effects of Exebacase (Lysin CF-301) Enhance Antimicrobial Activity against Staphylococcus aureus

Antimicrobial Agents & Chemotherapy, (2019) 63 (6) e02616-18

The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis

Antimicrobial Agents & Chemotherapy, (2019) 63 (4) e02291-18

Bacteriophage Lysin CF-301: a Potent Anti-Staphylococcal Biofilm Agent

Antimicrob. Agents Chemother (2017) 61 (7) e02666-16

Combination Therapy with Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus-Induced Murine Bacteremia

Journal of Infectious Diseases, (2014) 209 (9): 1469-1478.

Posters

PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

Presented at ID Week 2019, October 4, 2019

Exebacase (Lysin CF-301) Activity Against Staphylococcus aureus (S. aureus) Isolates from Bacteremic Patients Enrolled in a Phase 2 Study (CF-301-102)

Exebacase (Lysin CF-301) Activity Against Staphylococcus aureus (S. aureus) Isolates from Bacteremic Patients Enrolled in a Phase 2 Study (CF-301-102)

Presented at ID Week 2019, October 3, 2019

Activity of Exebacase (CF-301) Against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms on Orthopedic Kirschner Wires

Activity of Exebacase (CF-301) Against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms on Orthopedic Kirschner Wires

Presented at ID Week 2019, October 3, 2019

Impact of Dose-Administration Strategies of the Antistaphylococcal Lysin Exebacase, (CF-301), in Addition to Daptomycin (DAP) in an Experimental Infective Endocarditis (IE) Model due to Methicillin-Resistant Staphylococcus aureus (MRSA)

Impact of Dose-Administration Strategies of the Antistaphylococcal Lysin Exebacase, (CF-301), in Addition to Daptomycin (DAP) in an Experimental Infective Endocarditis (IE) Model due to Methicillin-Resistant Staphylococcus aureus (MRSA)

Presented at ID Week 2019, October 3, 2019

Amurin Peptide App2-M1 Eradicates Stenotrophomonas maltophilia Biofilms Formed on Hemodialysis Catheters in the Setting of Human Infection

Amurin Peptide App2-M1 Eradicates Stenotrophomonas maltophilia Biofilms Formed on Hemodialysis Catheters in the Setting of Human Infection

Presented at ASM-ESCMID 2019, September 4, 2019

CF-301 and Daptomycin Treatment of Methicillin-Resistant Staphylococcus aureus Associated Experimental Osteomyelitis

CF-301 and Daptomycin Treatment of Methicillin-Resistant Staphylococcus aureus Associated Experimental Osteomyelitis

Presented at ASM 2019, June 23, 2019

Lysins Exhibit Potent Bactericidal Activity, Synergy and Antibiofilm Effects against Pseudomonas aeruginosa in Human Serum and Pulmonary Surfactant

Lysins Exhibit Potent Bactericidal Activity, Synergy and Antibiofilm Effects against Pseudomonas aeruginosa in Human Serum and Pulmonary Surfactant

Presented at ASM 2019, June 23, 2019

Bacteriophage Lysin CF-301 (Exebacase) in Addition to Daptomycin in a Simulated Endocardial Vegetation (SEV) PK/PD Model

Bacteriophage Lysin CF-301 (Exebacase) in Addition to Daptomycin in a Simulated Endocardial Vegetation (SEV) PK/PD Model

Presented at ASM 2019, June 23, 2019

PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

PK-PD Relationship and PK Driver of Efficacy of the Novel Antibacterial Lysin Exebacase (CF-301) in Pre-Clinical Models

Presented at ASM 2019, June 21, 2019

Pharmacodynamic Assessment of Lysin CF-301 (exebacase) in Addition to Daptomycin against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model

Pharmacodynamic Assessment of Lysin CF-301 (exebacase) in Addition to Daptomycin against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model

Presented at ASM 2019, June 21, 2019

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