Nasdaq: CFRX

Activity of Exebacase (CF-301) against Biofilms Formed by Staphylococcus epidermidis Strains Isolated from Prosthetic Joint Infections

Lysins – a new armamentarium for the treatment of bone and joint infections?

Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistant Staphylococcus aureus implant-associated osteomyelitis

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

Exebacase in Addition to Daptomycin against MRSA

Exebacase Is Active In Vitro in Pulmonary Surfactant and Is Efficacious Alone and Synergistic with Daptomycin in a Mouse Model of Lethal Staphylococcus aureus Lung Infection

Activity of Lysin CF-296 Alone and in Addition to Daptomycin in a Rat Model of Experimental Methicillin-Resistant Staphylococcus aureus Osteomyelitis

Efficacy assessment of lysin CF-296 in addition to daptomycin or vancomycin against Staphylococcus aureus in the murine thigh infection model

Determination of MIC Quality Control Parameters for Exebacase, a Novel Lysin with Antistaphylococcal Activity

Development of a Broth Microdilution Method for Exebacase Susceptibility Testing

Engineered Lysins with Potent In Vitro Activity Against Burkholderia spp. and Yersinia pestis

PK-PD Relationships and PK Drivers of Efficacy of the Novel Antibacterial Lysin CF-370 in a Rabbit Pneumonia Model Caused by a Carbapenem-Resistant Pseudomonas aeruginosa

Efficacy of Lysin CF-370 in Addition to Amikacin or Meropenem in a Neutropenic Rabbit Lung Infection Model Caused by Klebsiella pneumoniae

Efficacy of Single and Daily Dose of Lysin CF-296 in Addition to Daptomycin in a Rat Methicillin-Resistant Staphylococcus aureus (MRSA) Osteomyelitis Model

Efficacy of lysin CF-370 in addition to amikacin in a neutropenic rabbit lung infection model caused by an extensively drug-resistant (XDR) P. aeruginosa

Activity of lysin CF-370 at the cell envelope of Gram-negative (GN) ESKAPE pathogens revealed by electron microscopy

Bacteriolytic and anti-virulence activities of engineered lysin CF-370 against Gram-negative (GN) ESKAPE pathogens

Lysin exebacase exerts potent in vitro bactericidal activity against Staphylococcus aureus strains associated with pulmonary exacerbations (PExs) of cystic fibrosis (CF)

Single center, exploratory, open-label prospective study using the minimally invasive LysinDAIR procedure (lysin administration during an arthroscopic DAIR procedure) in patients with suspected relapsing chronic coagulase-negative staphylococci (CNS) prosthetic hip infection (PHI)

Presented at IDWeek 2022, October 19, 2022

Locally Delivered Antistaphylococcal Lysins Exebacase or CF-296 is Active in Methicillin-Resistant Staphylococcus aureus Implant-associated Osteomyelitis